Single Cell News pinned «Dear colleagues! ⚡️ We’re taking a short summer breather to recharge. Hope your summer is filled with sunshine, adventure, and plenty of fun. We’ll be back in September - can’t wait to catch up then! 🏖️ All the best, ASCA Team #ASCAinfo»
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The ASCA is a global community of professionals who use the methods of single-cell analysis. The ASCA website
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Dear colleagues! ⚡️
We’re taking a short summer breather to recharge.
Hope your summer is filled with sunshine, adventure, and plenty of fun. We’ll be back in September - can’t wait to catch up then! 🏖️
All the best,
ASCA Team
#ASCAinfo
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A comprehensive epidermal map from a poplar single-cell shoot atlas reveals new trichome-specific genes
Anita Giabardo ... C. Robin Buell presented a single-cell RNA-seq atlas of the poplar 717 shoot, including apical meristem, primary and secondary stems, and three stages of leaf development.
Key points
🔹159,000 cells, 40 transcriptionally distinct clusters, and 7 major cell types
🔹Focus on the epidermis which constitutes >15% of cells in the shoot atlas
🔹Epidermal cell subclusters corresponding to developmental stages, spatial location, and specialized cell types
🔹Novel trichome markers
🔹A
HLiCA: An integrated cell atlas of the healthy human liver
Rachel Edgar ... Gary Bader presented the Human Liver Cell Atlas (HLiCA), an integrated reference of non-disease liver cells assembled from eight datasets across six research centers, encompassing more than 525,000 cells from 110 donors.
Key points
🔸 Expert-curated cell annotations
🔸 Classifying cells into six lineages and 47 distinct types
🔸 Evaluating the range of ancestral backgrounds represented in the atlas
🔸 Identification of previously unrecognized liver cell types, including NRXN1+ stromal cells localized to periportal regio
Pubertal maturation and chemotherapy-associated disruption of the pediatric ovary revealed by multimodal single-cell profiling
Loren Méar … Pauliina Damdimopoulou analyzed ovarian tissue from 16 patients undergoing fertility preservation (aged 1-16 years) and 11 adult controls (aged 22-32 years) using scRNA-seq, spatial transcriptomics, and multiplex immunostaining.
Key points
✔️ Extensive stromal remodeling across puberty, accompanied by vascular and neural maturation and a shift in germline transcriptional programs
✔️ Distinct tissue organization and follicular niche composition between
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